Dynactin 1 (DCTN1) (Middle Region) Peptide
DCTN1
Reactivité: Humain
Hôte: Synthetic
BP, WB
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- Antigène Tous les produits Dynactin 1 (DCTN1)
- Dynactin 1 (DCTN1)
- Protein Region
- Middle Region
- Origine
- Humain
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Séquence
- PYECLRQSCN ILISTMNKLA TAMQEGEYDA ERPPSKPPPV ELRAAALRAE
- Attributs du produit
- This is a synthetic peptide designed for use in combination with anti- DCTN1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Dynactin 1 (DCTN1) peptide
DCTN1 Reactivité: Humain, Souris, Rat Hôte: Synthetic BP, Imm
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- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Stock
- -20 °C
- Stockage commentaire
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Antigène
- Dynactin 1 (DCTN1)
- Synonymes
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DAP-150 Peptide, DP-150 Peptide, P135 Peptide, Chip150 Peptide, DCTN1 Peptide, DKFZp469C1813 Peptide, AL022633 Peptide, Glued Peptide, p150 Peptide, p150
Peptide, CG9206 Peptide, DYNA_DROME Peptide, Dmel\\CG9206 Peptide, FCP-D Peptide, Glu Peptide, P150 Peptide, P150[Glued] Peptide, p150/Glued Peptide, p150/glued Peptide, p150[Glued] Peptide, p150[glued] Peptide, t1 Peptide, Dynactin-1 Peptide, glued Peptide, dynactin subunit 1 Peptide, dynactin 1 Peptide, Dynactin 1, p150 subunit Peptide, dynactin subunit 1 L homeolog Peptide, DCTN1 Peptide, Dctn1 Peptide, DCTN1-p150 Peptide, dctn1.L Peptide - Sujet
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This gene encodes the largest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. Dynactin is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit interacts with dynein intermediate chain by its domains directly binding to dynein and binds to microtubules via a highly conserved glycine-rich cytoskeleton-associated protein (CAP-Gly) domain in its N-terminus. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause distal hereditary motor neuronopathy type VIIB (HMN7B) which is also known as distal spinal and bulbar muscular atrophy (dSBMA).
Alias Symbols: P135, DP-150, DAP-150
Protein Size: 1278 - ID gène
- 1639
- NCBI Accession
- NM_001135040, NP_001128512
- UniProt
- Q14203
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