Ubiquitin Interaction Motif Containing 1 (UIMC1) (Middle Region) Peptide
UIMC1
Reactivité: Humain
Hôte: Synthetic
BP, WB
N° du produit ABIN5511616
150,78 €
Plus frais de livraison 40,00 € et TVA
100 μg
Destination:
France
Envoi sous 15 à 22 jours ouvrables
Aperçu rapide pour Ubiquitin Interaction Motif Containing 1 (UIMC1) (Middle Region) Peptide (ABIN5511616)
Antigène
UIMC1
(Ubiquitin Interaction Motif Containing 1 (UIMC1))
Origine
Humain
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- Middle Region
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Séquence
- GIPFCPDGVD PNQYTKVILC QLEVYQKSLK MAQRQLLNKK GFGEPVLPRP
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Attributs du produit
- This is a synthetic peptide designed for use in combination with anti-UIMC1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Indications d'application
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Stock
- -20 °C
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Stockage commentaire
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- UIMC1 (Ubiquitin Interaction Motif Containing 1 (UIMC1))
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Sujet
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UIMC1 is a ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. It plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. It also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. It may interact with monoubiquitinated histones H2A and H2B, the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. And it may indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1.
Alias Symbols: UIMC1,RAP80, RXRIP110,
Protein Size: 641 -
ID gène
- 51720
Antigène
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