Glutamate Decarboxylase 1 (Brain, 67kDa) (GAD1) (N-Term) Peptide
GAD1
Reactivité: Humain
Hôte: Synthetic
BP, WB
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- Antigène Tous les produits GAD (GAD1)
- GAD (GAD1) (Glutamate Decarboxylase 1 (Brain, 67kDa) (GAD1))
- Protein Region
- N-Term
- Origine
- Humain
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Séquence
- CENSDRDARF RRTETDFSNL FARDLLPAKN GEEQTVQFLL EVVDILLNYV
- Attributs du produit
- This is a synthetic peptide designed for use in combination with anti-GAD1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Stock
- -20 °C
- Stockage commentaire
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Antigène
- GAD (GAD1) (Glutamate Decarboxylase 1 (Brain, 67kDa) (GAD1))
- Synonymes
- CPSQ1 Peptide, GAD Peptide, SCP Peptide, GAD-67 Peptide, cpsq1 Peptide, gad1 Peptide, gad1-A Peptide, gad67 Peptide, GAD67 Peptide, GAD1 Peptide, GLUTAMATE DECARBOXYLASE Peptide, GLUTAMATE DECARBOXYLASE 1 Peptide, MKP11.30 Peptide, MKP11_30 Peptide, glutamate decarboxylase Peptide, EP10 Peptide, GAD25 Peptide, GAD44 Peptide, Gad-1 Peptide, Gad67 Peptide, glutamate decarboxylase 1 Peptide, glutamate decarboxylase 1 L homeolog Peptide, glutamate decarboxylase Peptide, glutamate decarboxylase 1b Peptide, GAD1 Peptide, gad1.1.L Peptide, GAD Peptide, Gad1 Peptide, gad1b Peptide
- Sujet
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This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Deficiency in this enzyme has been shown to lead to pyridoxine dependency with seizures. Alternative splicing of this gene results in two products, the predominant 67-kD form and a less-frequent 25-kD form.
Alias Symbols: GAD, SCP, CPSQ1
Protein Size: 594 - ID gène
- 2571
- NCBI Accession
- NM_000817, NP_000808
- UniProt
- Q99259
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