Poly A Specific Ribonuclease (PARN) (Middle Region) Peptide
PARN
Reactivité: Humain
Hôte: Synthetic
BP, WB
N° du produit ABIN5511949
Aperçu rapide pour Poly A Specific Ribonuclease (PARN) (Middle Region) Peptide (ABIN5511949)
Antigène
PARN
(Poly A Specific Ribonuclease (PARN))
Origine
Humain
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- Middle Region
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Séquence
- CQSSSIDFLA SQGFDFNKVF RNGIPYLNQE EERQLREQYD EKRSQANGAG
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Attributs du produit
- This is a synthetic peptide designed for use in combination with anti-PARN Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Indications d'application
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Stock
- -20 °C
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Stockage commentaire
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- PARN (Poly A Specific Ribonuclease (PARN))
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Sujet
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The protein encoded by this gene is a 3'-exoribonuclease, with similarity to the RNase D family of 3'-exonucleases. It prefers poly(A) as the substrate, hence, efficiently degrades poly(A) tails of mRNAs. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs. This protein is also involved in silencing of certain maternal mRNAs during oocyte maturation and early embryonic development, as well as in nonsense-mediated decay (NMD) of mRNAs that contain premature stop codons. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: DAN, DKCB6, PFBMFT4
Protein Size: 639 -
ID gène
- 5073
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NCBI Accession
- NM_001134477, NP_001127949
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UniProt
- O95453
Antigène
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