AU RNA Binding Protein/enoyl-CoA Hydratase (AUH) (N-Term) Peptide
AUH
Reactivité: Humain
Hôte: Synthetic
BP, WB
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- Antigène Tous les produits AUH
- AUH (AU RNA Binding Protein/enoyl-CoA Hydratase (AUH))
- Protein Region
- N-Term
- Origine
- Humain
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Séquence
- IWAQGWVPAA GGPAPKRGYS SEMKTEDELR VRHLEEENRG IVVLGINRAY
- Attributs du produit
- This is a synthetic peptide designed for use in combination with anti-AUH Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Stock
- -20 °C
- Stockage commentaire
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Antigène
- AUH (AU RNA Binding Protein/enoyl-CoA Hydratase (AUH))
- Synonymes
- C77140 Peptide, W91705 Peptide, wu:fb81b10 Peptide, zgc:101057 Peptide, AU RNA binding methylglutaconyl-CoA hydratase Peptide, AU RNA binding protein/enoyl-coenzyme A hydratase Peptide, AU RNA binding protein/enoyl-CoA hydratase Peptide, AU RNA binding protein/enoyl-CoA hydratase S homeolog Peptide, AUH Peptide, Auh Peptide, auh Peptide, auh.S Peptide
- Sujet
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The methylglutaconyl-CoA hydratase, mitochondrial protein binds to the AU-rich element (ARE), a common element found in the 3' UTR of rapidly decaying mRNA such as c-fos, c-myc and granulocyte/ macrophage colony stimulating factor. ARE elements are involved in directing RNA to rapid degradation and deadenylation. AUH is also homologous to enol-CoA hydratase, an enzyme involved in fatty acid degradation, and has been shown to have intrinsic hydratase enzymatic activity. AUH is thus a bifunctional chimera between RNA binding and metabolic enzyme activity. A possible subcellular localization in the mitochondria has been demonstrated for the mouse homolog of this protein which shares 92 % identity with the human protein. It has been suggested that AUH may have a novel role as a mitochondrial located AU-binding protein. Human AUH is expressed as a single mRNA species of 1.8 kb, and translated as a 40- kDa precursor protein which is subsequently processed to a 32- kDa mature form.
Alias Symbols: AUH,
Protein Size: 339 - ID gène
- 549
- UniProt
- Q13825
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