G protein beta subunit-like (GBL) (N-Term) Peptide
GBL
Reactivité: Humain
Hôte: Synthetic
BP, WB
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- Antigène Tous les produits GBL
- GBL (G protein beta subunit-like (GBL))
- Protein Region
- N-Term
- Origine
- Humain
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Séquence
- TRTVQHQDSQ VNALEVTPDR SMIAAAGYQH IRMYDLNSNN PNPIISYDGV
- Attributs du produit
- This is a synthetic peptide designed for use in combination with anti-LST8 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Stock
- -20 °C
- Stockage commentaire
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Antigène
- GBL (G protein beta subunit-like (GBL))
- Synonymes
- gbl Peptide, lts8 Peptide, GBL Peptide, GbetaL Peptide, LST8 Peptide, POP3 Peptide, WAT1 Peptide, 0610033N12Rik Peptide, AA409454 Peptide, AI505104 Peptide, AI851821 Peptide, Gbl Peptide, fi37e04 Peptide, wu:fi37e04 Peptide, zgc:55455 Peptide, zgc:85668 Peptide, MTOR associated protein, LST8 homolog L homeolog Peptide, MTOR associated protein, LST8 homolog Peptide, MTOR associated protein, LST8 homolog (S. cerevisiae) Peptide, mlst8.L Peptide, MLST8 Peptide, Mlst8 Peptide, mlst8 Peptide
- Sujet
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LST8 is a subunit of both mTORC1 and mTORC2, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1- mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1 at 'Thr-389', which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Within mTORC1, LST8 interacts directly with MTOR and enhances its kinase activity. In nutrient- poor conditions, stabilizes the MTOR-RPTOR interaction and favors RPTOR-mediated inhibition of MTOR activity. mTORC2 is also activated by growth factors, but seems to be nutrient-insensitive.
Alias Symbols: MLST8,GBL, LST8,
Protein Size: 326 - ID gène
- 64223
- UniProt
- Q9BVC4
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