Caspase 8 (CASP8) (Middle Region) Peptide
CASP8
Reactivité: Humain
Hôte: Synthetic
BP, WB
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- Antigène Tous les produits Caspase 8 (CASP8)
- Caspase 8 (CASP8)
- Protein Region
- Middle Region
- Origine
- Humain
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Séquence
- SPDEFSNGEE LCGVMTISDS PREQDSESQT LDKVYQMKSK PRGYCLIINN
- Attributs du produit
- This is a synthetic peptide designed for use in combination with anti-CASP8 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Stock
- -20 °C
- Stockage commentaire
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Antigène
- Caspase 8 (CASP8)
- Synonymes
- casp8-A Peptide, xCaspase-8 Peptide, casp8 Peptide, CASP8 Peptide, CASP-8 Peptide, FLICE Peptide, MACH Peptide, Mch5 Peptide, ALPS2B Peptide, CAP4 Peptide, Casp-8 Peptide, MCH5 Peptide, caspase-8 Peptide, zgc:92075 Peptide, caspase 8 L homeolog Peptide, death related ced-3/Nedd2-like protein Peptide, caspase 8 Peptide, caspase-8 Peptide, caspase-8-like Peptide, caspase 8, apoptosis-related cysteine peptidase Peptide, casp8.L Peptide, LOC661095 Peptide, CASP8 Peptide, LOC5563818 Peptide, casp8 Peptide, LOC100222284 Peptide, Casp8 Peptide
- Sujet
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This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined.
Alias Symbols: CAP4, MACH, MCH5, FLICE, ALPS2B, Casp-8
Protein Size: 538 - ID gène
- 841
- NCBI Accession
- NM_001080124, NP_001073594
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