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Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3) (C-Term) Peptide

ERBB3 Reactivité: Humain Hôte: Synthetic BP, WB
N° du produit ABIN5512987
  • Antigène Tous les produits ERBB3
    ERBB3 (Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3))
    Protein Region
    C-Term
    Origine
    Humain
    Source
    • 8
    Synthetic
    Application
    Blocking Peptide (BP), Western Blotting (WB)
    Séquence
    SASLGSTQSC PLHPVPIMPT AGTTPDEDYE YMNRQRDGGG PGGDYAAMGA
    Attributs du produit
    This is a synthetic peptide designed for use in combination with anti- ERBB3 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
  • Indications d'application
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
    Stock
    -20 °C
    Stockage commentaire
    For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
  • Antigène
    ERBB3 (Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3))
    Synonymes
    ErbB-3 Peptide, HER3 Peptide, LCCS2 Peptide, MDA-BF-1 Peptide, c-erbB-3 Peptide, c-erbB3 Peptide, erbB3-S Peptide, p180-ErbB3 Peptide, p45-sErbB3 Peptide, p85-sErbB3 Peptide, ERBB3 Peptide, C76256 Peptide, Erbb-3 Peptide, Erbb3r Peptide, Her3 Peptide, nuc-ErbB3 Peptide, erb-b2 receptor tyrosine kinase 3 Peptide, v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) Peptide, ERBB3 Peptide, Erbb3 Peptide
    Sujet
    This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized.

    Alias Symbols: HER3, LCCS2, ErbB-3, c-erbB3, erbB3-S, MDA-BF-1, c-erbB-3, p180-ErbB3, p45-sErbB3, p85-sErbB3

    Protein Size: 699
    ID gène
    2065
    NCBI Accession
    NM_001005915, NP_001005915
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