Wiskott-Aldrich Syndrome (Eczema-thrombocytopenia) (WAS) (N-Term) Peptide
WAS
Reactivité: Humain
Hôte: Synthetic
BP, WB
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- Antigène Tous les produits WASP (WAS)
- WASP (WAS) (Wiskott-Aldrich Syndrome (Eczema-thrombocytopenia) (WAS))
- Protein Region
- N-Term
- Origine
- Humain
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Séquence
- IQKRNQRQSG DRRQLPPPPT PANEERRGGL PPLPLHPGGD QGGPPVGPLS
- Attributs du produit
- This is a synthetic peptide designed for use in combination with anti-WASP Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Stock
- -20 °C
- Stockage commentaire
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Antigène
- WASP (WAS) (Wiskott-Aldrich Syndrome (Eczema-thrombocytopenia) (WAS))
- Synonymes
- IMD2 Peptide, SCNX Peptide, THC Peptide, THC1 Peptide, WASP Peptide, U42471 Peptide, WASp Peptide, Wasp Peptide, imd2 Peptide, thc Peptide, thc1 Peptide, was Peptide, wasp Peptide, wu:fk81c08 Peptide, zgc:64164 Peptide, Wiskott-Aldrich syndrome Peptide, neural Wiskott-Aldrich syndrome protein Peptide, wiskott-aldrich syndrome protein Peptide, Wiskott-Aldrich syndrome L homeolog Peptide, Wiskott-Aldrich syndrome (eczema-thrombocytopenia) b Peptide, WAS Peptide, LOC5578888 Peptide, CpipJ_CPIJ006699 Peptide, Was Peptide, was.L Peptide, wasb Peptide
- Sujet
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The Wiskott-Aldrich syndrome (WAS) family of proteins share similar domain structure, and are involved in transduction of signals from receptors on the cell surface to the actin cytoskeleton. The presence of a number of different motifs suggests that they are regulated by a number of different stimuli, and interact with multiple proteins. Recent studies have demonstrated that these proteins, directly or indirectly, associate with the small GTPase, Cdc42, known to regulate formation of actin filaments, and the cytoskeletal organizing complex, Arp2/3. Wiskott-Aldrich syndrome is a rare, inherited, X-linked, recessive disease characterized by immune dysregulation and microthrombocytopenia, and is caused by mutations in the WAS gene. The WAS gene product is a cytoplasmic protein, expressed exclusively in hematopoietic cells, which show signalling and cytoskeletal abnormalities in WAS patients. A transcript variant arising as a result of alternative promoter usage, and containing a different 5' UTR sequence, has been described, however, its full-length nature is not known.
Alias Symbols: WAS,IMD2,
Protein Size: 502 - ID gène
- 7454
- NCBI Accession
- NP_000368
- UniProt
- P42768
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