Mannan-Binding Lectin Serine Peptidase 1 (MASP1) (Middle Region) Peptide
MASP1
Reactivité: Humain
Hôte: Synthetic
BP, WB
N° du produit ABIN5513766
Aperçu rapide pour Mannan-Binding Lectin Serine Peptidase 1 (MASP1) (Middle Region) Peptide (ABIN5513766)
Antigène
MASP1
(Mannan-Binding Lectin Serine Peptidase 1 (MASP1))
Origine
Humain
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- Middle Region
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Séquence
- VGPKVLGPFC GEKAPEPIST QSHSVLILFH SDNSGENRGW RLSYRAAGNE
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Attributs du produit
- This is a synthetic peptide designed for use in combination with anti-MASP1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Indications d'application
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Stock
- -20 °C
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Stockage commentaire
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- MASP1 (Mannan-Binding Lectin Serine Peptidase 1 (MASP1))
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Sujet
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This gene encodes a serine protease that functions as a component of the lectin pathway of complement activation. The complement pathway plays an essential role in the innate and adaptive immune response. The encoded protein is synthesized as a zymogen and is activated when it complexes with the pathogen recognition molecules of lectin pathway, the mannose-binding lectin and the ficolins. This protein is not directly involved in complement activation but may play a role as an amplifier of complement activation by cleaving complement C2 or by activating another complement serine protease, MASP-2. The encoded protein is also able to cleave fibrinogen and factor XIII and may may be involved in coagulation. A splice variant of this gene which lacks the serine protease domain functions as an inhibitor of the complement pathway. Alternate splicing results in multiple transcript variants.
Alias Symbols: MASP1,CRARF,CRARF1,PRSS5,
Protein Size: 380 -
ID gène
- 5648
Antigène
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