Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1) (C-Term) Peptide
CTNNB1
Reactivité: Humain
Hôte: Synthetic
BP, WB
N° du produit ABIN5672461
Aperçu rapide pour Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1) (C-Term) Peptide (ABIN5672461)
Antigène
CTNNB1
(Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1))
Origine
Humain
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- C-Term
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Séquence
- GLDIGAQGEP LGYRQDDPSY RSFHSGGYGQ DALGMDPMME HEMGGHHPGA
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Attributs du produit
- This is a synthetic peptide designed for use in combination with anti- CTNNB1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Indications d'application
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Stock
- -20 °C
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Stockage commentaire
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- CTNNB1 (Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1))
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Sujet
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The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Three transcript variants encoding the same protein have been found for this gene.
Alias Symbols: EVR7, CTNNB, MRD19, armadillo
Protein Size: 781 -
ID gène
- 1499
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NCBI Accession
- NM_001098209, NP_001091679
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UniProt
- P35222
Antigène
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