TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 1 (TAB1) (N-Term) Peptide
TAB1
Reactivité: Humain
Hôte: Synthetic
BP, WB
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- Antigène Tous les produits TAB1
- TAB1 (TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 1 (TAB1))
- Protein Region
- N-Term
- Origine
- Humain
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Séquence
- DDLPLCHLSG VGSASNRSYS ADGKGTESHP PEDSWLKFRS ENNCFLYGVF
- Attributs du produit
- This is a synthetic peptide designed for use in combination with anti- TAB1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Stock
- -20 °C
- Stockage commentaire
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Antigène
- TAB1 (TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 1 (TAB1))
- Synonymes
- 3'-Tab1 Peptide, MAP3K7IP1 Peptide, 2310012M03Rik Peptide, Map3k7ip1 Peptide, b2b449Clo Peptide, TGF-beta activated kinase 1 (MAP3K7) binding protein 1 Peptide, TGF-beta activated kinase 1/MAP3K7 binding protein 1 Peptide, TAB1 Peptide, Tab1 Peptide
- Sujet
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The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
Alias Symbols: 3&apos, -Tab1, MAP3K7IP1
Protein Size: 504 - ID gène
- 10454
- NCBI Accession
- NM_006116, NP_006107
- UniProt
- Q15750
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