Damage-Specific DNA Binding Protein 2, 48kDa (DDB2) (C-Term) Peptide
Aperçu rapide pour Damage-Specific DNA Binding Protein 2, 48kDa (DDB2) (C-Term) Peptide (ABIN8098515)
Antigène
Origine
Source
Application
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Protein Region
- C-Term
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Fonction
- DDB2 Peptide - C-terminal region
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Séquence
- IVVGRYPDPN FKSCTPYELR TIDVFDGNSG KMMCQLYDPE SSGISSLNEF
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Indications d'application
- Optimal working dilution should be determined by the investigator.
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Commentaires
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This is a synthetic peptide designed for use in combination with anti-DDB2 Antibody (ARP60163_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 µL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Buffer
- Lyophilized powder
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Stock
- -20 °C
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Stockage commentaire
- For longer periods of storage, store at -20 °C. Avoid repeat freeze-thaw cycles.
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- DDB2 (Damage-Specific DNA Binding Protein 2, 48kDa (DDB2))
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Sujet
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Background Information: This gene encodes a protein that is necessary for the repair of ultraviolet light-damaged DNA. This protein is the smaller subunit of a heterodimeric protein complex that participates in nucleotide excision repair, and this complex mediates the ubiquitylation of histones H3 and H4, which facilitates the cellular response to DNA damage. This subunit appears to be required for DNA binding. Mutations in this gene cause xeroderma pigmentosum complementation group E, a recessive disease that is characterized by an increased sensitivity to UV light and a high predisposition for skin cancer development, in some cases accompanied by neurological abnormalities.
Alternative Symbols: DDBB, FLJ34321, UV-DDB2
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Poids moléculaire
- 48kDa
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ID gène
- 1643
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NCBI Accession
- NP_000098
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UniProt
- Q92466
Antigène
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