Fibroblast Growth Factor Receptor 2 (FGFR2) (Middle Region) Peptide
Aperçu rapide pour Fibroblast Growth Factor Receptor 2 (FGFR2) (Middle Region) Peptide (ABIN8100664)
Antigène
Origine
Source
Application
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Protein Region
- Middle Region
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Fonction
- FGFR2 Peptide - middle region
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Séquence
- KHVEKNGSKY GPDGLPYLKV LKHSGINSSN AEVLALFNVT EADAGEYICK
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Fibroblast Growth Factor Receptor 2 (FGFR2) peptide
FGFR2 Reactivité: Humain, Souris, Boeuf (Vache), Chien, Porc, Rat Hôte: Synthetic BP, Imm
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Indications d'application
- Optimal working dilution should be determined by the investigator.
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Commentaires
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This is a synthetic peptide designed for use in combination with anti-FGFR2 Antibody (ARP60045_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 µL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Buffer
- Lyophilized powder
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Stock
- -20 °C
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Stockage commentaire
- For longer periods of storage, store at -20 °C. Avoid repeat freeze-thaw cycles.
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- FGFR2 (Fibroblast Growth Factor Receptor 2 (FGFR2))
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Sujet
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Background Information: The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
Alternative Symbols: BEK, BFR-1, CD332, CEK3, CFD1, ECT1, FLJ98662, JWS, K-SAM, KGFR, TK14, TK25
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Poids moléculaire
- 78kDa
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ID gène
- 2263
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NCBI Accession
- NP_075259
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UniProt
- P21802
Antigène
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