Frizzled Family Receptor 9 (FZD9) Peptide
Aperçu rapide pour Frizzled Family Receptor 9 (FZD9) Peptide (ABIN8101000)
Antigène
Source
Application
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Fonction
- FZD9 Peptide
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Indications d'application
- Optimal working dilution should be determined by the investigator.
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Commentaires
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This is a synthetic peptide designed for use in combination with anti-FZD9 antibody ( ARP41253_T100). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 µL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Buffer
- Lyophilized powder
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Stock
- -20 °C
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Stockage commentaire
- For longer periods of storage, store at -20 °C. Avoid repeat freeze-thaw cycles.
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- FZD9 (Frizzled Family Receptor 9 (FZD9))
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Sujet
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Background Information: FZD9 contains 1 FZ (frizzled) domain and belongs to the G-protein coupled receptor Fz/Smo family. It is receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members. It may be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD9 gene is located within the Williams syndrome common deletion region of chromosome 7, and heterozygous deletion of the FZD9 gene may contribute to the Williams syndrome phenotype. FZD9 is expressed predominantly in brain, testis, eye, skeletal muscle, and kidney.
Alternative Symbols: FZD3, CD349
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Poids moléculaire
- 65kDa
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ID gène
- 8326
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NCBI Accession
- NP_003499
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UniProt
- O00144
Antigène
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