Mdc1 (MDC1) (C-Term) Peptide
Aperçu rapide pour Mdc1 (MDC1) (C-Term) Peptide (ABIN8104973)
Antigène
Origine
Source
Application
-
-
Protein Region
- C-Term
-
Fonction
- MDC1 Peptide - C-terminal region
-
Séquence
- GKEEDVVTPK PGKRKRDQAE EEPNRIPSRS LRRTKLNQES TAPKVLFTGV
-
-
-
-
Indications d'application
- Optimal working dilution should be determined by the investigator.
-
Commentaires
-
This is a synthetic peptide designed for use in combination with anti-MDC1 Antibody,. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
-
Restrictions
- For Research Use only
-
-
-
Format
- Lyophilized
-
Reconstitution
- Add 100 µL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
-
Buffer
- Lyophilized powder
-
Stock
- -20 °C
-
Stockage commentaire
- For longer periods of storage, store at -20 °C. Avoid repeat freeze-thaw cycles.
-
-
- MDC1 (Mdc1 (MDC1))
-
Sujet
-
Background Information: The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci.
Alternative Symbols: DKFZp781A0122, KIAA0170, MGC166888, NFBD1
-
Poids moléculaire
- 227kDa
-
ID gène
- 9656
-
NCBI Accession
- NP_055456
-
UniProt
- Q14676
Antigène
-
