MutS Homolog 6 (E. Coli) (MSH6) (Middle Region) Peptide
Aperçu rapide pour MutS Homolog 6 (E. Coli) (MSH6) (Middle Region) Peptide (ABIN8105877)
Antigène
Origine
Source
Application
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Protein Region
- Middle Region
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Fonction
- MSH6 Peptide - middle region
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Séquence
- MVVPDKISEV VELLKKLPDL ERLLSKIHNV GSPLKSQNHP DSRAIMYEET
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Indications d'application
- Optimal working dilution should be determined by the investigator.
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Commentaires
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This is a synthetic peptide designed for use in combination with anti- MSH6 Antibody (ARP87348_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 µL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Buffer
- Lyophilized powder
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Stock
- -20 °C
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Stockage commentaire
- For longer periods of storage, store at -20 °C. Avoid repeat freeze-thaw cycles.
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- MSH6 (MutS Homolog 6 (E. Coli) (MSH6))
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Sujet
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Background Information: This gene encodes a member of the DNA mismatch repair MutS family. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein heterodimerizes with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene may be associated with hereditary nonpolyposis colon cancer, colorectal cancer, and endometrial cancer. Transcripts variants encoding different isoforms have been described.
Alternative Symbols: GTBP, HSAP, p160, GTMBP, HNPCC5
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Poids moléculaire
- 153 kDa
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ID gène
- 2956
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NCBI Accession
- NP_000170
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UniProt
- P52701
Antigène
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