Non-POU Domain Containing, Octamer-Binding (NONO) Peptide
Aperçu rapide pour Non-POU Domain Containing, Octamer-Binding (NONO) Peptide (ABIN8106609)
Antigène
Source
Application
-
-
Fonction
- NONO Peptide
-
-
-
-
Indications d'application
- Optimal working dilution should be determined by the investigator.
-
Commentaires
-
This is a synthetic peptide designed for use in combination with anti-NONO antibody ( ARP40716_T100). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
-
Restrictions
- For Research Use only
-
-
-
Format
- Lyophilized
-
Reconstitution
- Add 100 µL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
-
Buffer
- Lyophilized powder
-
Stock
- -20 °C
-
Stockage commentaire
- For longer periods of storage, store at -20 °C. Avoid repeat freeze-thaw cycles.
-
-
- NONO (Non-POU Domain Containing, Octamer-Binding (NONO))
-
Sujet
-
Background Information: NONO is DNA- and RNA binding protein, involved in several nuclear processes. It binds the conventional octamer sequence in double stranded DNA. It also binds single-stranded DNA and RNA at a site independent of the duplex site. It is involved in pre-mRNA splicing and interacts with U5 snRNA. The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs, be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1 and be involved in DNA nonhomologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends. NONO binds to an enhancer element in long terminal repeats of endogenous intracisternal A particles (IAPs) and activates transcription.
Alternative Symbols: P54, NMT55, NRB54, P54NRB
-
Poids moléculaire
- 52kDa
-
ID gène
- 4841
-
NCBI Accession
- NP_031389
-
UniProt
- Q15233
Antigène
-
