Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 8 (PSMD8) Peptide

This is a synthetic peptide designed for use in combination with anti-PSMD8 antibody ( ARP48216_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.

Targeted Subunit: 8

Background Information: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. PSMD8 is a non-ATPase subunit of the 19S regulator. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides.

Alternative Symbols: HIP6, HYPF, MGC1660, Nin1p, Rpn12, S14, p31