A synthetic peptide for use as a blocking control in assays to test for specificity of IARS antibody, Alternative Names: IARS control peptide, IARS antibody Blocking Peptide, Anti-IARS Blocking Peptide, Isoleucyl-tRNA Synthetase Blocking Peptide, FLJ20736 Blocking Peptide, IARS1 Blocking Peptide, ILRS Blocking Peptide, PRO0785 Blocking Peptide
Purification
Affinity chromatography using phosphopeptide and cross-adsorbed with the corresponding non-phosphopeptide.
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAS, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Isoleucine-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family and has been identified as a target of autoantibodies in the autoimmune disease polymyositis/dermatomyositis. Two alternatively spliced variants have been isolated that represent alternate 5' UTRs.