SH2 Domain Containing 1A (SH2D1A) Peptide
SH2D1A
Reactivité: Mammifères
Hôte: Synthetic
BP, WB, IHC
N° du produit ABIN936059
Aperçu rapide pour SH2 Domain Containing 1A (SH2D1A) Peptide (ABIN936059)
Antigène
SH2D1A
(SH2 Domain Containing 1A (SH2D1A))
Origine
Mammifères
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
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Type de proteíne
- Synthetic
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Séquence
- YFRKIKNLIS AFQKPDQGIV IPLQYPVEKK SSARSTQGTT GIREDPDVCL
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Attributs du produit
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A synthetic peptide for use as a blocking control in assays to test for specificity of SH2 D2 antibody,
Alternative Names: SH2D1A control peptide, SH2D1A antibody Blocking Peptide, Anti-SH2D1A Blocking Peptide, SH2 domain protein 1A Blocking Peptide, DSHP Blocking Peptide, EBVS Blocking Peptide, FLJ18687 Blocking Peptide, FLJ92177 Blocking Peptide, IMD5 Blocking Peptide, LYP Blocking Peptide, MTCP1 Blocking Peptide, SAP Blocking Peptide, XLP Blocking Peptide, XLPD Blocking Peptide, SH2D1A, SHD1A-2, SHD1A 2, SHD1A-2 Blocking Peptide, SHD1A 2 Blocking Peptide
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Indications d'application
- Optimal conditions should be determined by the investigator
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 µL of distilled water for a final peptide concentration is 1 mg/mL.
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Buffer
- PBS
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Conseil sur la manipulation
- Avoid repeated freeze/thaw cycles.
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Stock
- -20 °C
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Stockage commentaire
- Store at -20 °C long term.
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- SH2D1A (SH2 Domain Containing 1A (SH2D1A))
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Sujet
- SH2D1A is a protein that plays a major role in the bidirectional stimulation of T and B cells. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in SH2D1A gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma.
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Poids moléculaire
- 14 kDa
Antigène
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