A synthetic peptide for use as a blocking control in assays to test for specificity of AGK antibody, Alternative Names: AGK control peptide, AGK antibody Blocking Peptide, Anti-AGK Blocking Peptide, acylglycerol kinase Blocking Peptide, FLJ10842 Blocking Peptide, MULK Blocking Peptide
AGK is a lipid kinase that can phosphorylate both monoacylglycerol and diacylglycerol to form lysophosphatidic acid (LPA) and phosphatidic acid (PA), respectively. AGK does not phosphorylate sphingosine. Overexpression of AGK increases the formation and secretion of LPA, resulting in transactivation of EGFR and activation of the downstream MAPK signaling pathway, leading to increased cell growth.