A synthetic peptide for use as a blocking control in assays to test for specificity of A1 CF antibody, Alternative Names: A1CF control peptide, A1CF antibody Blocking Peptide, Anti-A1CF Blocking Peptide, Apobec1 Complementation Factor Blocking Peptide, ACF Blocking Peptide, ACF64 Blocking Peptide, ACF65 Blocking Peptide, APOBEC1CF Blocking Peptide, ASP Blocking Peptide, MGC163391 Blocking Peptide, RP11-564C4.2 Blocking Peptide
Mammalian apolipoprotein B mRNA undergoes site-specific C to U deamination, which is mediated by a multi-component enzyme complex containing a minimal core composed of APOBEC-1 and a complementation factor encoded by this gene. A1CF has three non-identical RNA recognition motifs and belongs to the hnRNP R family of RNA-binding proteins. It has been proposed that this complementation factor functions as an RNA-binding subunit and docks APOBEC-1 to deaminate the upstream cytidine. Studies suggest that the protein may also be involved in other RNA editing or RNA processing events.