DNA (Cytosine-5-)-Methyltransferase 3 beta (DNMT3B) Peptide
DNMT3B
Reactivité: Mammifères
Hôte: Synthetic
BP, WB, IHC
N° du produit ABIN938993
Aperçu rapide pour DNA (Cytosine-5-)-Methyltransferase 3 beta (DNMT3B) Peptide (ABIN938993)
Antigène
DNMT3B
(DNA (Cytosine-5-)-Methyltransferase 3 beta (DNMT3B))
Origine
Mammifères
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
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Type de proteíne
- Synthetic
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Séquence
- GTGRLFFEFY HLLNYSRPKE GDDRPFFWMF ENVVAMKVGD KRDISRFLEC
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Attributs du produit
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A synthetic peptide for use as a blocking control in assays to test for specificity of DNMT3 B antibody,
Alternative Names: DNMT3B control peptide, DNMT3B antibody Blocking Peptide, Anti-DNMT3B Blocking Peptide, Dna Blocking Peptide, Cytosine-5-Methyltransferase 3 Beta Blocking Peptide, ICF Blocking Peptide, M.HsaIIIB Blocking Peptide, DNMT3B, DNMTB-3, DNMTB 3, DNMTB-3 Blocking Peptide, DNMTB 3 Blocking Peptide
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Indications d'application
- Optimal conditions should be determined by the investigator
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 µL of distilled water for a final peptide concentration is 1 mg/mL.
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Buffer
- PBS
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Conseil sur la manipulation
- Avoid repeated freeze/thaw cycles.
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Stock
- -20 °C
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Stockage commentaire
- Store at -20 °C long term.
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- DNMT3B (DNA (Cytosine-5-)-Methyltransferase 3 beta (DNMT3B))
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Sujet
- DNMT3B is required for genome wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. DNMT3B may preferentially methylate nucleosomal DNA within the nucleosome core region. DNMT3B may function as transcriptional co-repressor by associating with CBX4 and independently of DNA methylation. DNMT3B seems to be involved in gene silencing. In association with DNMT1 and via the recruitment of CTCFL/BORIS, DNMT3B is involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9.
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Poids moléculaire
- 86 kDa
Antigène
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