Cyclin D1 (CCND1) Peptide
CCND1
Reactivité: Mammifères
Hôte: Synthetic
BP, WB, IHC
N° du produit ABIN939653
Aperçu rapide pour Cyclin D1 (CCND1) Peptide (ABIN939653)
Antigène
Cyclin D1 (CCND1)
Origine
Mammifères
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
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Type de proteíne
- Synthetic
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Séquence
- KCEEEVFPLA MNYLDRFLSL EPVKKSRLQL LGATCMFVAS KMKETIPLTA
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Attributs du produit
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A synthetic peptide for use as a blocking control in assays to test for specificity of CCND1 antibody,
Alternative Names: CCND1 control peptide, CCND1 antibody Blocking Peptide, Anti-CCND1 Blocking Peptide, cyclin D1 Blocking Peptide, BCL1 Blocking Peptide, D11S287E Blocking Peptide, PRAD1 Blocking Peptide, U21B31 Blocking Peptide, CCND1, CCND-1, CCND 1, CCND-1 Blocking Peptide, CCND 1 Blocking Peptide
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Indications d'application
- Optimal conditions should be determined by the investigator
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 µL of distilled water for a final peptide concentration is 1 mg/mL.
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Buffer
- PBS
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Conseil sur la manipulation
- Avoid repeated freeze/thaw cycles.
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Stock
- -20 °C
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Stockage commentaire
- Store at -20 °C long term.
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- Cyclin D1 (CCND1)
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Sujet
- CCND1 belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. CCND1 has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.
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Poids moléculaire
- 34 kDa
Antigène
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