A synthetic peptide for use as a blocking control in assays to test for specificity of Bmp10 antibody, Alternative Names: Bmp10 control peptide, Bmp10 antibody Blocking Peptide, Anti-Bmp10 Blocking Peptide, bone morphogenetic protein 10 Blocking Peptide, Bmp10 Blocking Peptide, Bmp10, Bmp-10, Bmp 10, Bmp-10 Blocking Peptide, Bmp 10 Blocking Peptide
Optimal conditions should be determined by the investigator
Restrictions
For Research Use only
Format
Lyophilized
Reconstitution
Add 100 µL of distilled water for a final peptide concentration is 1 mg/mL.
Buffer
PBS
Conseil sur la manipulation
Avoid repeated freeze/thaw cycles.
Stock
-20 °C
Stockage commentaire
Store at -20 °C long term.
Antigène
BMP10
(Bone Morphogenetic Protein 10 (BMP10))
Sujet
Bmp10 is required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Bmp10 acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Bmp10 inhibits endothelial cell migration and growth.