A synthetic peptide for use as a blocking control in assays to test for specificity of RAD18 antibody, Alternative Names: RAD18 control peptide, RAD18 antibody Blocking Peptide, Anti-RAD18 Blocking Peptide, Rad18 Homolog Blocking Peptide, RNF73 Blocking Peptide, RAD18, RAD-18, RAD 18, RAD-18 Blocking Peptide, RAD 18 Blocking Peptide
Optimal conditions should be determined by the investigator
Restrictions
For Research Use only
Format
Lyophilized
Reconstitution
Add 100 µL of distilled water for a final peptide concentration is 1 mg/mL.
Buffer
PBS
Conseil sur la manipulation
Avoid repeated freeze/thaw cycles.
Stock
-20 °C
Stockage commentaire
Store at -20 °C long term.
Antigène
RAD18
(E3 ubiquitin-protein ligase RAD18 (RAD18))
Sujet
RAD18 is highly similar to S. cerevisiae DNA damage repair protein Rad18. Yeast Rad18 functions through its interaction with Rad6, which is an ubiquitin-conjugating enzyme required for post-replication repair of damaged DNA. Similar to its yeast counterpart, RAD18 is able to interact with the human homolog of yeast Rad6 protein through a conserved ring-finger motif. Mutation of this motif results in defective replication of UV-damaged DNA and hypersensitivity to multiple mutagens.