A synthetic peptide for use as a blocking control in assays to test for specificity of Tcea3 antibody, Alternative Names: Tcea3 control peptide, Tcea3 antibody Blocking Peptide, Anti-Tcea3 Blocking Peptide, transcription elongation factor A, SII, 3 Blocking Peptide, S-II Blocking Peptide, SII-K1 Blocking Peptide, Tcea3, Tcea-3, Tcea 3, Tcea-3 Blocking Peptide, Tcea 3 Blocking Peptide
Optimal conditions should be determined by the investigator
Restrictions
For Research Use only
Format
Lyophilized
Reconstitution
Add 100 µL of distilled water for a final peptide concentration is 1 mg/mL.
Buffer
PBS
Conseil sur la manipulation
Avoid repeated freeze/thaw cycles.
Stock
-20 °C
Stockage commentaire
Store at -20 °C long term.
Antigène
TCEA3
(Transcription Elongation Factor A (SII), 3 (TCEA3))
Sujet
Tcea3 is necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.