Amiloride-Sensitive Cation Channel 2, Neuronal (ACCN2) (N-Term) Peptide
ACCN2
Reactivité: Humain
Hôte: Synthetic
BP, WB
N° du produit ABIN972801
Aperçu rapide pour Amiloride-Sensitive Cation Channel 2, Neuronal (ACCN2) (N-Term) Peptide (ABIN972801)
Antigène
ASIC1 (ACCN2)
(Amiloride-Sensitive Cation Channel 2, Neuronal (ACCN2))
Origine
Humain
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- N-Term
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Attributs du produit
- This is a synthetic peptide designed for use in combination with anti-ACCN2 antibody (Catalog #: ARP35298_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Amiloride-Sensitive Cation Channel 2, Neuronal (ACCN2) peptide
ACCN2 Hôte: Synthetic BP, WB, IHC
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Indications d'application
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
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Stock
- -20 °C
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Stockage commentaire
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- ASIC1 (ACCN2) (Amiloride-Sensitive Cation Channel 2, Neuronal (ACCN2))
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Sujet
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ACCN2 is the cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. ACCN2 is also permeable for Ca2+, Li+ and K+. ACCN2 generates a biphasic current with a fast inactivating and a slow sustained phase. ACCN2 mediates glutamate-independent Ca2+ entry into neurons upon acidosis. This Ca2+ overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. Heteromeric channel assembly seems to modulate channel properties. ACCN2 functions as a postsynaptic proton receptor that influences intracellular Ca2+ concentration and calmodulin-dependent protein kinase II phosphorylation and thereby the density of dendritic spines. It modulates activity in the circuits underlying innate fear.This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene is expressed in most if not all brain neurons, and it may be an ion channel subunit, however, its function as an ion channel remains unknown. Alternative splicing of this gene generates 2 transcript products.
Alias Symbols: ASIC, ASIC1A, BNaC2, hBNaC2, ACCN2
Protein Interaction Partner: PICK1,ACCN1,ACCN2,PICK1,PRKACA,STOM,PICK1,PRKACA,STOML1
Protein Size: 574 -
Poids moléculaire
- 65 kDa
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ID gène
- 41
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NCBI Accession
- NM_020039, NP_064423
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UniProt
- P78348
Antigène
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