Actinin, alpha 2 (ACTN2) Peptide
ACTN2
Reactivité: Humain
Hôte: Synthetic
BP, WB, IHC
N° du produit ABIN972867
Aperçu rapide pour Actinin, alpha 2 (ACTN2) Peptide (ABIN972867)
Antigène
ACTN2
(Actinin, alpha 2 (ACTN2))
Origine
Humain
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
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Attributs du produit
- This is a synthetic peptide designed for use in combination with anti-ACTN2 antibody (Catalog #: ARP41463_T100). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Indications d'application
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
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Stock
- -20 °C
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Stockage commentaire
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- ACTN2 (Actinin, alpha 2 (ACTN2))
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Sujet
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The alpha-actinins are a multigene family of four actin-binding proteins related to dystrophin. The two skeletal muscle isoforms of alpha-actinin (ACTN2 and ACTN3) are major structural components of the Z-line involved in anchoring the actin-containing thin filaments. In humans, ACTN2 is expressed in all muscle fibres, while ACTN3 expression is restricted to a subset of type 2 fibres. Murine Actn2 and Actn3 are differentially expressed, spatially and temporally, during embryonic development and, in contrast to humans, alpha-actinin-2 expression does not completely overlap alpha-actinin-3 in postnatal skeletal muscle, suggesting independent function.Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a muscle-specific, alpha actinin isoform that is expressed in both skeletal and cardiac muscles. Transcript variants resulting from the use of multiple poly_A sites have been observed.
Alias Symbols: CMD1AA
Protein Interaction Partner: ANG,CAPN1,DISC1,GRIN1,LDB3,MYOZ1,ACTN2,ACTN3,ADAM12,ADORA2A,ANG,ATXN2,CAMK2A,CAMK2D,CAMK2G,CAPN1,COIL,DISC1,DLG1,DLG4,EPS8L1,GRIN1,GRIN2B,KAT2B,KCNA4,KCNA5,LDB3,LRP12,LRRC7,MED14,MYOZ1,MYOZ2,MYOZ3,MYPN,NCOA2,NCOR1,NR1I2,NRIP1,PALLD,PDLIM1,PKD2,RAVER1,SELE,SNW1,SSX2IP,TTN,UTRN,ACTN3,ADAM12,DISC1,DLG1,DLG4,GRIN2B,KCNA5,LDB3,MYOZ1,MYPN,PDLIM1,ST7,TNN,Tuba1a
Protein Size: 894 -
Poids moléculaire
- 98 kDa
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ID gène
- 88
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NCBI Accession
- NM_001103, NP_001094
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UniProt
- P35609
Antigène
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