Autoimmune Regulator (AIRE) Peptide
AIRE
Reactivité: Humain
Hôte: Synthetic
BP, WB
N° du produit ABIN973039
Aperçu rapide pour Autoimmune Regulator (AIRE) Peptide (ABIN973039)
Antigène
AIRE
(Autoimmune Regulator (AIRE))
Origine
Humain
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Attributs du produit
- This is a synthetic peptide designed for use in combination with anti-AIRE antibody (Catalog #: ARP31969_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Indications d'application
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
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Stock
- -20 °C
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Stockage commentaire
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- AIRE (Autoimmune Regulator (AIRE))
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Sujet
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The function of the protein encoded by the AIRE gene is not well defined. However it contains zinc finger motifs suggestive of a transcription factor. The protein (isoform 1) is localized to both the nucleus and cytoplasm. Defects in this gene cause the autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED).This gene encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CBP. At least three splice variant mRNAs products have been described including one which results in a premature stop codon and a transcript predicted to be a candidate for nuclear-mediated decay (NMD). Defects in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED).
Alias Symbols: AIRE1, APECED, APS1, APSI, PGA1
Protein Interaction Partner: AIRE,CREBBP,AIRE,CREBBP,AIRE,CHD6,CREBBP,DDX17,DDX5,EFTUD2,GEMIN5,HIST1H2AC,HIST1H2BO,IPO7,KPNB1,LMNB1,MCM2,MCM5,MCM6,MSH2,MSH6,MYBBP1A,NASP,NOP56,NUP93,PABPC1,PARP1,PCNA,POLR2A,POLR2B,PRKDC,RAD21,RANBP2,RANBP9,RUVBL2,SMC1A,SMC3,SNRPB,SNRPD3,SRSF1,SRSF2,SRSF3,SSRP1,TOP2A,TRIM28,XPO1,XPOT
Protein Size: 545 -
Poids moléculaire
- 58 kDa
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ID gène
- 326
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NCBI Accession
- NM_000383, NP_000374
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UniProt
- O43918
Antigène
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