Apurinic/Apyrimidinic Endonuclease 1 (APEX1) (N-Term) Peptide
APEX1
Reactivité: Humain
Hôte: Synthetic
BP, WB
N° du produit ABIN973300
Aperçu rapide pour Apurinic/Apyrimidinic Endonuclease 1 (APEX1) (N-Term) Peptide (ABIN973300)
Antigène
APEX1
(Apurinic/Apyrimidinic Endonuclease 1 (APEX1))
Origine
Humain
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- N-Term
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Séquence
- MPKRGKKGAV AEDGDELRTE PEAKKSKTAA KKNDKEAAGE GPALYEDPPD
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Attributs du produit
- This is a synthetic peptide designed for use in combination with anti-APEX1 Antibody(ARP58027_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Indications d'application
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
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Stock
- -20 °C
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Stockage commentaire
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- APEX1 (Apurinic/Apyrimidinic Endonuclease 1 (APEX1))
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Sujet
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Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes the major AP endonuclease in human cells. Splice variants have been found for this gene, all encode the same protein.
Alias Symbols: APE, APE1, APEN, APEX, APX, HAP1, REF-1, REF1
Protein Interaction Partner: CDKN1A,MUTYH,TP53,ANP32A,ANP32C,APEX1,CSNK2A1,DCTN1,EP300,FEN1,GZMA,HDAC1,HIF1A,HMGB2,HNRNPL,HSPA1A,MUTYH,NME1,NXF2,PCNA,POLB,SET,TP53,TXN,UBE2I,XRCC1,XRCC6,ANP32A,FEN1,HIF1A,HNRNPL,MUTYH,PCNA,SET,TP53,XRCC1,XRCC5
Protein Size: 318 -
Poids moléculaire
- 35 kDa
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ID gène
- 328
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NCBI Accession
- NM_001641, NP_001632
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UniProt
- P27695
Antigène
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