Achaete-Scute Complex Homolog 1 (Drosophila) (ASCL1) (Middle Region) Peptide
ASCL1
Reactivité: Humain
Hôte: Synthetic
BP, WB
N° du produit ABIN973495
Aperçu rapide pour Achaete-Scute Complex Homolog 1 (Drosophila) (ASCL1) (Middle Region) Peptide (ABIN973495)
Antigène
ASCL1
(Achaete-Scute Complex Homolog 1 (Drosophila) (ASCL1))
Origine
Humain
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- Middle Region
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Attributs du produit
- This is a synthetic peptide designed for use in combination with anti-ASCL1 antibody (Catalog #: AVARP00017_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Indications d'application
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
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Stock
- -20 °C
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Stockage commentaire
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- ASCL1 (Achaete-Scute Complex Homolog 1 (Drosophila) (ASCL1))
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Sujet
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ASCL1 may play a role at early stages of development of specific neural lineages in most regions of the CNS, and of several lineages in the PNS. ASCL1 is essential for the generation of olfactory and autonomic neurons. ASCL1 activates transcription by binding to the E box (5'-CANNTG-3').This gene encodes a member of the basic helix-loop-helix (BHLH) family of transcription factors. The protein activates transcription by binding to the E box (5'-CANNTG-3'). Dimerization with other BHLH proteins is required for efficient DNA binding. This protein plays a role in the neuronal commitment and differentiation and in the generation of olfactory and autonomic neurons. Mutations in this gene may contribute to the congenital central hypoventilation syndrome (CCHS) phenotype in rare cases. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: ASH1, HASH1, MASH1, bHLHa46
Protein Interaction Partner: ASCL1,BMP2,EP300,MEF2A,NEUROG2,TCF4,UBQLN1,EP300,MEF2A,TCF4
Protein Size: 236 -
Poids moléculaire
- 25 kDa
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ID gène
- 429
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NCBI Accession
- NM_004316, NP_004307
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UniProt
- P50553
Antigène
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