Calreticulin (CALR) Peptide
CALR
Reactivité: Humain
Hôte: Synthetic
BP, WB, IHC
N° du produit ABIN974409
Aperçu rapide pour Calreticulin (CALR) Peptide (ABIN974409)
Antigène
Calreticulin (CALR)
Origine
Humain
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
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Attributs du produit
- This is a synthetic peptide designed for use in combination with anti-CALR antibody (Catalog #: ARP30114_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Calreticulin (CALR) peptide (Ovalbumin)
CALR Reactivité: Humain Hôte: Synthetic WB, Imm, SDS
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Indications d'application
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
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Stock
- -20 °C
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Stockage commentaire
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Calreticulin (CALR)
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Sujet
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Calreticulin is a multifunctional protein that acts as a major Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. It is also found in the nucleus, suggesting that it may have a role in transcription regulation. Calreticulin binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid sequence in the DNA-binding domain of the superfamily of nuclear receptors. Calreticulin binds to antibodies in certain sera of systemic lupus and Sjogren patients which contain anti-Ro/SSA antibodies, it is highly conserved among species, and it is located in the endoplasmic and sarcoplasmic reticulum where it may bind calcium.
Alias Symbols: RO, CRT, SSA, cC1qR
Protein Interaction Partner: CALR,HLA-A,PDIA3,TSHR,APOB,APP,AR,B2M,CALR,CD1D,F5,F8,FBN1,FGB,HLA-C,ITGA2B,ITGA3,ITGAV,LPL,LRP1,MBL2,MTNR1A,NKX2-1,NR3C1,PDIA2,PDIA3,PLAT,PLP1,PRF1,SCARF1,SLC2A1,SLC6A4,SUMO4,TAPBP,TF,THBS1,TSHR,VWF,APOB,APP,AR,CANX,CD1D,CD40,ELF3,EPB41,F5,FGB,LRP1,MBL2,NKX2-1,NR3C1,PDIA3,PLAT,PRF1,SLC2A1,SLC6A4,TAPBP,TF,VWF
Protein Size: 417 -
Poids moléculaire
- 48 kDa
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ID gène
- 811
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NCBI Accession
- NM_004343, NP_004334
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UniProt
- P27797
Antigène
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