Caspase 3 (CASP3) (C-Term) Peptide
CASP3
Reactivité: Humain
Hôte: Synthetic
BP, WB, IHC
N° du produit ABIN974474
Aperçu rapide pour Caspase 3 (CASP3) (C-Term) Peptide (ABIN974474)
Antigène
Caspase 3 (CASP3)
Origine
Humain
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
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Protein Region
- C-Term
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Séquence
- NLKYEVRNKN DLTREEIVEL MRDVSKEDHS KRSSFVCVLL SHGEEGIIFG
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Attributs du produit
- This is a synthetic peptide designed for use in combination with anti-CASP3 Antibody(ARP58987_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Indications d'application
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
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Stock
- -20 °C
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Stockage commentaire
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Caspase 3 (CASP3)
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Sujet
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CASP3 is a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein.
Alias Symbols: CPP32, CPP32B, SCA-1
Protein Interaction Partner: AR,ATN1,ATXN3,BIRC3,BIRC6,HTT,NDUFS1,NEO1,PARP1,PLEKHO1,XIAP,BIRC6,CFLAR,PSEN1,RB1,XIAP,ACIN1,ADD1,AIFM1,AKAP8,AKT1,APAF1,APP,AR,ARHGDIB,ATN1,BCAP31,BCAR1,BCL2,BID,BIRC2,BIRC3,BIRC5,BIRC6,BIRC7,BLM,BMX,BRCA1,CAD,CASP10,CASP3,CASP4,CASP6,CASP8,CASP9,CAST,C
Protein Size: 277 -
Poids moléculaire
- 12 kDa
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ID gène
- 836
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NCBI Accession
- NM_032991, NP_116786
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UniProt
- P42574
Antigène
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