This is a synthetic peptide designed for use in combination with anti-CD3E Antibody(ARP59097_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women.
Alias Symbols: FLJ18683, T3E, TCRE
Protein Interaction Partner: CD3D,CD3EAP,CD3G,CD79B,LCK,NCK1,NCK2,NCL,PIK3R1,PTPN22,SHC1,SYK,TOP2B,TRAT1,UNC119,ZAP70,CD3EAP,CD3G,JAK3,NCK1,NCK2,NCL,PIK3R1,SYK,TOP2B,ZAP70