CCAAT/enhancer Binding Protein (C/EBP), alpha (CEBPA) (Middle Region) Peptide
CEBPA
Reactivité: Humain
Hôte: Synthetic
BP, WB, IHC
N° du produit ABIN974817
Aperçu rapide pour CCAAT/enhancer Binding Protein (C/EBP), alpha (CEBPA) (Middle Region) Peptide (ABIN974817)
Antigène
CEBPA
(CCAAT/enhancer Binding Protein (C/EBP), alpha (CEBPA))
Origine
Humain
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
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Protein Region
- Middle Region
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Attributs du produit
- This is a synthetic peptide designed for use in combination with anti-CEBPA antibody (Catalog #: ARP57937_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Indications d'application
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
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Stock
- -20 °C
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Stockage commentaire
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- CEBPA (CCAAT/enhancer Binding Protein (C/EBP), alpha (CEBPA))
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Sujet
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CEBPA is a bZIP transcription factor which can bind as a homodimer to certain promoters and enhancers. It can form heterodimers with the related proteins CEBP-beta and CEBP-gamma. The protein has been shown to bind to the promoter and modulate the expression of the gene encoding leptin, a protein that plays an important role in body weight homeostasis. Also, CEBPA can interact with CDK2 and CDK4, thereby inhibiting these kinases and causing growth arrest in cultured cells.The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain promoters and enhancers. It can also form heterodimers with the related proteins CEBP-beta and CEBP-gamma. The encoded protein has been shown to bind to the promoter and modulate the expression of the gene encoding leptin, a protein that plays an important role in body weight homeostasis. Also, the encoded protein can interact with CDK2 and CDK4, thereby inhibiting these kinases and causing growth arrest in cultured cells. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-2385 U34070.1 592-2976
Alias Symbols: C/EBP-alpha, CEBP
Protein Interaction Partner: LTF,NCOA6,PIAS1,ATF2,CDK2,CDK4,CDKN1A,CDKN3,CDX1,CEBPA,CEBPB,CEBPD,CREBBP,CTNNB1,DBP,EP300,GATA2,GSK3B,HNF1A,MSX2,MYC,NCOA6,NFYA,NR3C1,PIAS1,RB1,RBL1,RFC1,RUNX1,SOX10,SOX8,SPI1,SUMO3,AR,ATF2,Atf2,CDK2,CDK4,CEBPB,CTNNB1,ESR1,MAPK8,MSX2,MYC,NCOA6,NR3C1,RARB,SMAD3,SMAD4,SPI1,UBC
Protein Size: 358 -
Poids moléculaire
- 37 kDa
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ID gène
- 1050
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NCBI Accession
- NM_004364, NP_004355
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UniProt
- P49715
Antigène
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