Cholinergic Receptor, Nicotinic, beta 3 (Neuronal) (CHRNB3) Peptide
CHRNB3
Reactivité: Humain
Hôte: Synthetic
BP, WB
N° du produit ABIN974961
Aperçu rapide pour Cholinergic Receptor, Nicotinic, beta 3 (Neuronal) (CHRNB3) Peptide (ABIN974961)
Antigène
CHRNB3
(Cholinergic Receptor, Nicotinic, beta 3 (Neuronal) (CHRNB3))
Origine
Humain
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
-
-
Attributs du produit
- This is a synthetic peptide designed for use in combination with anti-CHRNB3 antibody (Catalog #: AVARP13021_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
-
Purification
- Purified
-
-
Cholinergic Receptor, Nicotinic, beta 3 (Neuronal) (CHRNB3) peptide
CHRNB3 Reactivité: Humain, Souris, Rat Hôte: Synthetic BP, Imm
-
-
Indications d'application
- Each Investigator should determine their own optimal working dilution for specific applications.
-
Restrictions
- For Research Use only
-
-
-
Format
- Lyophilized
-
Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
-
Concentration
- 1 mg/mL
-
Buffer
- Final peptide concentration is 1 mg/mL in PBS.
-
Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
-
Stock
- -20 °C
-
Stockage commentaire
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
-
-
- CHRNB3 (Cholinergic Receptor, Nicotinic, beta 3 (Neuronal) (CHRNB3))
-
Sujet
-
Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels nAChRs are pentameric structures that are made up of combinations of individual subunits. CHRNB3 is one of the subunits of nAChR. Twelve neuronal nAChR subunits have been described, alpha2-alpha10 and beta2-beta4. CHRNB3 decreased the channel mean open time and burst length. There was also an increase in single channel slope conductance. On the other hand, the calcium permeability and the pharmacological properties of beta3-containing receptors differed little from those of without beta3. Dysfunction of nAChR has been linked to a number of human diseases such as schizophrenia, Alzheimer's and Parkinson's diseases. nAChRs also play a significant role in nicotine addiction.
Protein Size: 458 -
Poids moléculaire
- 53 kDa
-
ID gène
- 1142
-
NCBI Accession
- NM_000749, NP_000740
-
UniProt
- Q05901
Antigène
-
Vous êtes ici:
