24-Dehydrocholesterol Reductase (DHCR24) Peptide
DHCR24
Reactivité: Humain, Souris
Hôte: Synthetic
BP, WB
N° du produit ABIN975752
Aperçu rapide pour 24-Dehydrocholesterol Reductase (DHCR24) Peptide (ABIN975752)
Antigène
Seladin 1 (DHCR24)
(24-Dehydrocholesterol Reductase (DHCR24))
Origine
Humain, Souris
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Attributs du produit
- This is a synthetic peptide designed for use in combination with anti-DHCR24 antibody (Catalog #: ARP47072_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Indications d'application
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
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Stock
- -20 °C
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Stockage commentaire
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Seladin 1 (DHCR24) (24-Dehydrocholesterol Reductase (DHCR24))
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Sujet
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DHCR24 is a flavin adenine dinucleotide (FAD)-dependent oxidoreductase which catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. The protein contains a leader sequence that directs it to the endoplasmic reticulum membrane. Missense mutations in this gene have been associated with desmosterolosis. Also, reduced expression of the gene occurs in the temporal cortex of Alzheimer disease patients and overexpression has been observed in adrenal gland cancer cells.This gene encodes a flavin adenine dinucleotide (FAD)-dependent oxidoreductase which catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. The protein contains a leader sequence that directs it to the endoplasmic reticulum membrane. Missense mutations in this gene have been associated with desmosterolosis. Also, reduced expression of the gene occurs in the temporal cortex of Alzheimer disease patients and overexpression has been observed in adrenal gland cancer cells. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: KIAA0018, Nbla03646, SELADIN1, seladin-1, DCE
Protein Interaction Partner: MDM2,TP53,TP53
Protein Size: 516 -
Poids moléculaire
- 58 kDa
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ID gène
- 1718
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NCBI Accession
- NM_014762, NP_055577
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UniProt
- Q15392
Antigène
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