Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 8 (ERCC8) Peptide
ERCC8
Reactivité: Humain, Souris
Hôte: Synthetic
BP, WB
N° du produit ABIN976414
Aperçu rapide pour Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 8 (ERCC8) Peptide (ABIN976414)
Antigène
ERCC8
(Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 8 (ERCC8))
Origine
Humain, Souris
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Attributs du produit
- This is a synthetic peptide designed for use in combination with anti-ERCC8 antibody (Catalog #: ARP32149_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Indications d'application
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
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Stock
- -20 °C
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Stockage commentaire
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- ERCC8 (Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 8 (ERCC8))
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Sujet
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ERCC8 is a WD repeat protein, which interacts with Cockayne syndrome type B (CSB) protein and with p44 protein, a subunit of the RNA polymerase II transcription factor IIH. Mutations in this gene have been identified in patients with hereditary disease Cockayne syndrome (CS). This gene encodes a WD repeat protein, which interacts with Cockayne syndrome type B (CSB) protein and with p44 protein, a subunit of the RNA polymerase II transcription factor IIH. Mutations in this gene have been identified in patients with hereditary disease Cockayne syndrome (CS). CS cells are abnormally sensitive to ultraviolet radiation and are defective in the repair of transcriptionally active genes.
Alias Symbols: CKN1, CSA
Protein Interaction Partner: CBR1,DDB1,ERCC6,GTF2H2,UQCRQ,XAB2,COPS5,COPS6,CUL4A,CUL4B,DDB1,XAB2
Protein Size: 396 -
Poids moléculaire
- 44 kDa
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ID gène
- 1161
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NCBI Accession
- NM_000082, NP_000073
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UniProt
- Q13216
Antigène
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