Gap Junction Protein, alpha 1, 43kDa (GJA1) (Middle Region) Peptide
GJA1
Reactivité: Humain
Hôte: Synthetic
BP, WB
N° du produit ABIN977414
Aperçu rapide pour Gap Junction Protein, alpha 1, 43kDa (GJA1) (Middle Region) Peptide (ABIN977414)
Antigène
Connexin 43/GJA1 (GJA1)
(Gap Junction Protein, alpha 1, 43kDa (GJA1))
Origine
Humain
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- Middle Region
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Attributs du produit
- This is a synthetic peptide designed for use in combination with anti-GJA1 antibody (Catalog #: ARP36597_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Indications d'application
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
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Stock
- -20 °C
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Stockage commentaire
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Connexin 43/GJA1 (GJA1) (Gap Junction Protein, alpha 1, 43kDa (GJA1))
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Sujet
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Gap junction protein, alpha 1 is a member of the connexin gene family and a component of gap junctions. Gap junctions are composed of arrays of intercellular channels and provide a route for the diffusion of materials of low molecular weight from cell to cell. Connexin 43 is the major protein of gap junctions in the heart, and gap junctions are thought to have a crucial role in the synchronized contraction of the heart and in embryonic development. Connexin 43 is targeted by several protein kinases that regulate myocardial cell-cell coupling. A related intron-less connexin 43 pseudogene, GJA1P, has been mapped to chromosome 5. This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. The encoded protein is the major protein of gap junctions in the heart that are thought to have a crucial role in the synchronized contraction of the heart and in embryonic development. A related intronless pseudogene has been mapped to chromosome 5. Mutations in this gene have been associated with oculodentodigital dysplasia and heart malformations. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: CX43, DFNB38, GJAL, ODDD, HSS, AVSD3, HLHS1
Protein Interaction Partner: SRC,CAV1,CSK,CSNK1D,GJA3,GJA5,MAPK1,MAPK3,MAPK7,NOV,PRKCA,PRKCB,PRKCE,PRKCG,S100A1,SGSM3,SRC,TJP1,CAV1,CSNK1D,GJA1,GJA3,GJA5,MAPK7,PRKCA,PRKCE,S100A1,TJP1
Protein Size: 382 -
Poids moléculaire
- 43 kDa
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ID gène
- 2697
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NCBI Accession
- NM_000165, NP_000156
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UniProt
- P17302
Antigène
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