Hydroxycarboxylic Acid Receptor 2 (HCAR2) (C-Term) Peptide
HCAR2
Reactivité: Humain
Hôte: Synthetic
BP, WB
N° du produit ABIN977876
Aperçu rapide pour Hydroxycarboxylic Acid Receptor 2 (HCAR2) (C-Term) Peptide (ABIN977876)
Antigène
HCAR2
(Hydroxycarboxylic Acid Receptor 2 (HCAR2))
Origine
Humain
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
-
-
Protein Region
- C-Term
-
Séquence
- YYFSSPSFPN FFSTLINRCL QRKMTGEPDN NRSTSVELTG DPNKTRGAPE
-
Attributs du produit
- This is a synthetic peptide designed for use in combination with anti-HCAR2 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
-
Purification
- Purified
-
-
Hydroxycarboxylic Acid Receptor 2 (HCAR2) peptide
HCAR2 Hôte: Synthetic BP, WB, IHC
-
-
Indications d'application
- Each Investigator should determine their own optimal working dilution for specific applications.
-
Restrictions
- For Research Use only
-
-
-
Format
- Lyophilized
-
Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
-
Concentration
- 1 mg/mL
-
Buffer
- Final peptide concentration is 1 mg/mL in PBS.
-
Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
-
Stock
- -20 °C
-
Stockage commentaire
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
-
-
- HCAR2 (Hydroxycarboxylic Acid Receptor 2 (HCAR2))
-
Sujet
-
HCAR2 acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. The rank order of potency for the displacement of nicotinic acid binding is 5-methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid > acifran > 5-methyl nicotinic acid = acipimox >> nicotinuric acid = nicotinamide.
Alias Symbols: HM74a, HM74b, NIACR1, PUMAG, Puma-g
Protein Size: 363 -
Poids moléculaire
- 42 kDa
-
ID gène
- 338442
-
NCBI Accession
- NM_177551, NP_808219
-
UniProt
- Q8TDS4
Antigène
-
Vous êtes ici:
