Insulin-Degrading Enzyme (IDE) (N-Term) Peptide
IDE
Reactivité: Humain
Hôte: Synthetic
BP, WB
N° du produit ABIN978389
Aperçu rapide pour Insulin-Degrading Enzyme (IDE) (N-Term) Peptide (ABIN978389)
Antigène
IDE
(Insulin-Degrading Enzyme (IDE))
Origine
Humain
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- N-Term
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Séquence
- LDVHIGSLSD PPNIAGLSHF CEHMLFLGTK KYPKENEYSQ FLSEHAGSSN
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Attributs du produit
- This is a synthetic peptide designed for use in combination with anti-IDE Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Indications d'application
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
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Stock
- -20 °C
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Stockage commentaire
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- IDE (Insulin-Degrading Enzyme (IDE))
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Sujet
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This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion.
Alias Symbols: FLJ35968, INSULYSIN
Protein Interaction Partner: APP,AR,IGF1,IGF2,INS,NR3C1,IGF1,IGF2,ZHX2
Protein Size: 1019 -
Poids moléculaire
- 118 kDa
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ID gène
- 3416
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NCBI Accession
- NM_004969, NP_004960
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UniProt
- P14735
Antigène
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