Interleukin 7 Receptor (IL7R) (Middle Region) Peptide
IL7R
Reactivité: Humain
Hôte: Synthetic
BP, WB
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- Antigène Tous les produits IL7R
- IL7R (Interleukin 7 Receptor (IL7R))
- Protein Region
- Middle Region
- Origine
- Humain
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Séquence
- ESFLDCQIHR VDDIQARDEV EGFLQDTFPQ QLEESEKQRL GGDVQSPNCP
- Attributs du produit
- This is a synthetic peptide designed for use in combination with anti-IL7R Antibody(ARP59084_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Indications d'application
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Antigène
- IL7R (Interleukin 7 Receptor (IL7R))
- Synonymes
- IL7R Peptide, CD127 Peptide, IL-7Ralpha Peptide, CDW127 Peptide, IL-7R-alpha Peptide, IL7RA Peptide, ILRA Peptide, IL-7RA Peptide, interleukin 7 receptor Peptide, IL7R Peptide, Il7r Peptide
- Sujet
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The protein encoded by this gene is a receptor for interleukine 7 (IL7). The function of this receptor requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including interleukine 2, 4, 7, 9, and 15. This protein has been shown to play a critical role in the V(D)J recombination during lymphocyte development. This protein is also found to control the accessibility of the TCR gamma locus by STAT5 and histone acetylation. Knockout studies in mice suggested that blocking apoptosis is an essential function of this protein during differentiation and activation of T lymphocytes. The functional defects in this protein may be associated with the pathogenesis of the severe combined immunodeficiency (SCID).
Alias Symbols: CD127, CDW127, IL-7R-alpha, IL7RA, ILRA
Protein Interaction Partner: IL7,CRLF2,FYN,IL2RG,IL7,JAK1,JAK3,LYN,PIK3R1,PTK2B,STAT3,STAT5A,STAT5B,TSLP,FYN,PTK2B
Protein Size: 459 - Poids moléculaire
- 49 kDa
- ID gène
- 3575
- NCBI Accession
- NM_002185, NP_002176
- UniProt
- P16871
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