Inhibitor of Growth Family, Member 3 (ING3) (N-Term) Peptide
ING3
Reactivité: Humain, Souris
Hôte: Synthetic
BP, IHC, WB
N° du produit ABIN978549
Aperçu rapide pour Inhibitor of Growth Family, Member 3 (ING3) (N-Term) Peptide (ABIN978549)
Antigène
ING3
(Inhibitor of Growth Family, Member 3 (ING3))
Origine
Humain, Souris
Source
Synthetic
Application
Blocking Peptide (BP), Immunohistochemistry (IHC), Western Blotting (WB)
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Protein Region
- N-Term
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Attributs du produit
- This is a synthetic peptide designed for use in combination with anti-ING3 antibody (Catalog #: ARP33346_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Indications d'application
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
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Stock
- -20 °C
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Stockage commentaire
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- ING3 (Inhibitor of Growth Family, Member 3 (ING3))
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Sujet
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ING3 is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This gene can activate p53 trans-activated promoters, including promoters of p21/waf1 and bax. Overexpression of this gene has been shown to inhibit cell growth and induce apoptosis. Allelic loss and reduced expression of this gene were detected in head and neck cancers.The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This gene can activate p53 trans-activated promoters, including promoters of p21/waf1 and bax. Overexpression of this gene has been shown to inhibit cell growth and induce apoptosis. Allelic loss and reduced expression of this gene were detected in head and neck cancers. Two alternatively spliced transcript variants encoding different isoforms have been observed.
Alias Symbols: Eaf4, FLJ20089, ING2, p47ING3, MEAF4
Protein Interaction Partner: NR1H2,NR1H3,ACTL6A,BRD8,DMAP1,EPC1,EPC2,HHT1,HHT2,KAT5,MEAF6,MORF4L1,RUVBL1,RUVBL2,TRRAP,YEATS4
Protein Size: 418 -
Poids moléculaire
- 47 kDa
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ID gène
- 54556
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NCBI Accession
- NM_019071, NP_061944
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UniProt
- Q9NXR8
Antigène
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