Insulin Induced Gene 1 (INSIG1) (Middle Region) Peptide
INSIG1
Reactivité: Humain
Hôte: Synthetic
BP, WB
N° du produit ABIN978564
Aperçu rapide pour Insulin Induced Gene 1 (INSIG1) (Middle Region) Peptide (ABIN978564)
Antigène
INSIG1
(Insulin Induced Gene 1 (INSIG1))
Origine
Humain
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- Middle Region
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Attributs du produit
- This is a synthetic peptide designed for use in combination with anti-INSIG1 antibody (Catalog #: ARP40162_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Indications d'application
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
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Stock
- -20 °C
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Stockage commentaire
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- INSIG1 (Insulin Induced Gene 1 (INSIG1))
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Sujet
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Oxysterols regulate cholesterol homeostasis through the liver X receptor (LXR)- and sterol regulatory element-binding protein (SREBP)-mediated signaling pathways. This gene is an insulin-induced gene. INSIG1 is an endoplasmic reticulum (ER) membrane protein that plays a critical role in regulating cholesterol concentrations in cells. INSIG1 binds to the sterol-sensing domains of SREBP cleavage-activating protein (SCAP) and HMG CoA reductase, and is essential for the sterol-mediated trafficking of the two proteins. Oxysterols regulate cholesterol homeostasis through liver X receptor (LXR) and sterol regulatory element-binding protein (SREBP) mediated signaling pathway. This gene is an insulin-induced gene. It encodes an endoplasmic reticulum (ER) membrane protein that plays a critical role in regulating cholesterol concentrations in cells. This protein binds to the sterol-sensing domains of SREBP cleavage-activating protein (SCAP) and HMG CoA reductase, and is essential for the sterol-mediated trafficking of the two proteins. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
Alias Symbols: CL-6, MGC1405, CL6
Protein Interaction Partner: HMGCR,SCAP,SREBF2,FAF2,PGRMC1,SCAP,SCAP,SREBF2,Scap,VCP
Protein Size: 330 -
Poids moléculaire
- 36 kDa
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ID gène
- 3638
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NCBI Accession
- NM_198336, NP_938150
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UniProt
- A4D2M9
Antigène
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