Insulin Receptor (INSR) (Middle Region) Peptide
INSR
Reactivité: Humain
Hôte: Synthetic
BP, WB, IHC
N° du produit ABIN978572
Aperçu rapide pour Insulin Receptor (INSR) (Middle Region) Peptide (ABIN978572)
Antigène
Insulin Receptor (INSR)
Origine
Humain
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
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Protein Region
- Middle Region
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Attributs du produit
- This is a synthetic peptide designed for use in combination with anti-INSR antibody (Catalog #: AVARP08005_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Indications d'application
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
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Stock
- -20 °C
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Stockage commentaire
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Insulin Receptor (INSR)
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Sujet
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This receptor binds insulin and has a tyrosine-protein kinase activity. Isoform Short has a higher affinity for insulin. INSR mediates the metabolic functions of insulin. INSR binding to insulin stimulates association of the receptor with downstream mediators including IRS1 and phosphatidylinositol 3'-kinase (PI3K). INSR can activate PI3K either directly by binding to the p85 regulatory subunit, or indirectly via IRS1. When present in a hybrid receptor with IGF1R, it binds IGF1.A report shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, another report shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin.After removal of the precursor signal peptide, the insulin receptor precursor is post-translationally cleaved into two chains (alpha and beta) that are covalently linked. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. Two transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: CD220, HHF5
Protein Interaction Partner: HMGA1,CSK,GRB10,IRS1,IRS1,IRS2,JAK1,PIK3R1,PIK3R1,SHC1,SOCS1,SOCS6,ACP1,ADRB2,AHSG,ARF1,ARHGAP26,CALM1,CALM3,CALM3,CAV1,CAV3,CBL,CEACAM1,CRK,CRKL,CSK,DOK1,DOK4,DOK5,ENPP1,FABP4,FRS2,GAB1,GNB2L1,GRB10,GRB14,GRB7,HRAS,IGF1R,IGF2,INS,INSR,INSRR,IRS1,IRS2,JAK1,JAK2,KHDRBS1,KRT27,MAD2L1,MAPK3,PIK3R1,PIK3R3,PLCG1,PRKCA,PRKCD,PTK2,PTPN1,PTPN11,PTPN12,PTPN2,PTPN6,PTPRC,PTPRF,RAF1,RASA1,SH2B1,SH2B2,SHC1,SMAD2,SNX1,SNX2,SNX4,SNX6,SOCS1,SOCS2,SOCS3,SOCS6,SORBS1,SRC,STAT5A,STAT5B,SYNCRIP,VAV1,VAV3,YWHAB,AHSG,CAV1,CSK,ENPP1,FRS2,GRB10,GRB14,GRB2,GRB7,Grb14,HRAS,INPPL1,INSRR,IRS1,IRS2,JAK2,KHDRBS1,MAPK1,MAPK3,PRKCD,PTPN1,PTPN11,PTPN6,RASA1,SH2B1,SHC1,SMAD2,SNX1,SNX2,SNX4,SNX6,SOCS3,SORBS1,SYNCRIP,VAV1,VAV3
Protein Size: 1382 -
Poids moléculaire
- 154 kDa
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ID gène
- 3643
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NCBI Accession
- NM_000208, NP_000199
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UniProt
- P06213
Antigène
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