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Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) (C-Term) Peptide

MANF Reactivité: Humain Hôte: Synthetic BP, WB
N° du produit ABIN979757
  • Antigène Tous les produits MANF
    MANF (Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF))
    Protein Region
    C-Term
    Origine
    Humain
    Source
    • 4
    Synthetic
    Application
    Blocking Peptide (BP), Western Blotting (WB)
    Séquence
    EKICEKLKKK DSQICELKYD KQIDLSTVDL KKLRVKELKK ILDDWGETCK
    Attributs du produit
    This is a synthetic peptide designed for use in combination with anti-MANF Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
    Purification
    Purified
  • Indications d'application
    Each Investigator should determine their own optimal working dilution for specific applications.
    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
    Concentration
    1 mg/mL
    Buffer
    Final peptide concentration is 1 mg/mL in PBS.
    Conseil sur la manipulation
    Avoid repeated freeze-thaw cycles.
    Stock
    -20 °C
    Stockage commentaire
    For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
  • Antigène
    MANF (Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF))
    Synonymes
    ARMET Peptide, ARP Peptide, 3230402M22Rik Peptide, AA407711 Peptide, AA408789 Peptide, AA673178 Peptide, Armet Peptide, D17914 Peptide, D18Mgi17 Peptide, MANF Peptide, RBM15B Peptide, ARP-like Peptide, CG7013 Peptide, DmMANF Peptide, Dmel\\CG7013 Peptide, anon-EST:ParkEST188 Peptide, arp Peptide, armet Peptide, im:6909481 Peptide, zgc:153327 Peptide, manf Peptide, mesencephalic astrocyte derived neurotrophic factor Peptide, mesencephalic astrocyte-derived neurotrophic factor Peptide, RNA binding motif protein 15B Peptide, Mesencephalic astrocyte-derived neurotrophic factor Peptide, mesencephalic astrocyte-derived neurotrophic factor S homeolog Peptide, MANF Peptide, Manf Peptide, RBM15B Peptide, manf Peptide, manf.S Peptide
    Sujet
    MANF is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Reducing expression of MANF gene increases susceptibility to ER stress-induced death and promotes cell proliferation. The protein was initially thought to be longer at the N-terminus and to contain an arginine-rich region but transcribed evidence indicates a smaller open reading frame that does not encode the arginine tract. The presence of polymorphisms in the arginine-rich region, including a specific mutation that changes the previously numbered codon 50 from ATG to AGG, have been reported in a variety of solid tumors, however, these polymorphisms were later shown to exist in normal tissues and are thus not tumor-related.

    Alias Symbols: ARMET, ARP, MGC142148, MGC142150

    Protein Size: 185
    Poids moléculaire
    21 kDa
    ID gène
    7873
    NCBI Accession
    NM_006010, NP_006001
    UniProt
    A8K878
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