Myelin Basic Protein (MBP) (Middle Region) Peptide
MBP
Reactivité: Humain
Hôte: Synthetic
WB, BP
N° du produit ABIN979878
Aperçu rapide pour Myelin Basic Protein (MBP) (Middle Region) Peptide (ABIN979878)
Antigène
MBP
(Myelin Basic Protein (MBP))
Origine
Humain
Source
Synthetic
Application
Western Blotting (WB), Blocking Peptide (BP)
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Protein Region
- Middle Region
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Attributs du produit
- This is a synthetic peptide designed for use in combination with anti-MBP antibody (Catalog #: ARP56223_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Myelin Basic Protein (MBP) peptide (Ovalbumin)
MBP Reactivité: Humain Hôte: Synthetic WB, Imm, SDS
Myelin Basic Protein (MBP) peptide (Ovalbumin)MBP Reactivité: Humain Hôte: Synthetic WB, Imm, SDS
Myelin Basic Protein (MBP) peptide (Ovalbumin)MBP Reactivité: Humain Hôte: Synthetic WB, Imm, SDS
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Indications d'application
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
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Stock
- -20 °C
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Stockage commentaire
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- MBP (Myelin Basic Protein (MBP))
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Sujet
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The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. MBP induces T-cell proliferation.The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long MBP gene (otherwise called 'Golli-MBP') that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to MBP aa sequence. The second family of transcripts contain only MBP exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the MBP transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes.
Alias Symbols: MGC99675
Protein Interaction Partner: MAPK1,PRKCA,PRKCD,PRKCI,PRKCZ,ROCK1,ROCK2,APTX,ATN1,ATXN1,BMP2K,CDK12,CLK1,CTDSP1,DYRK1B,EFHA1,HLA-DRA,IRAK1,MAG,MAPK1,MAPK11,MAPK13,MAPK14,MAPK15,MAPK3,MAPKAPK5,MELK,MKNK1,MMP7,MST4,NEK9,PAK1,PLP1,PRKACA,PRKCA,PRKCD,PRKCI,PRKCZ,PRMT1,PRMT5,RAN,RPS6KA5,RTN4,SRPK1,STK16,STK39,STK4,TLK1,TLK2,TRAF6,TRPM7,HLA-DRA,PLP1,PRMT5,STK39,TRPM7
Protein Size: 304 -
Poids moléculaire
- 33 kDa
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ID gène
- 4155
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NCBI Accession
- NM_001025101, NP_001020272
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UniProt
- P02686
Antigène
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