O6-Methylguanine-DNA-Methyltransferase (MGMT) (Middle Region) Peptide
MGMT
Reactivité: Humain
Hôte: Synthetic
BP, WB
N° du produit ABIN980068
Aperçu rapide pour O6-Methylguanine-DNA-Methyltransferase (MGMT) (Middle Region) Peptide (ABIN980068)
Antigène
MGMT
(O6-Methylguanine-DNA-Methyltransferase (MGMT))
Origine
Humain
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- Middle Region
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Séquence
- ISYQQLAALA GNPKAARAVG GAMRGNPVPI LIPCHRVVCS SGAVGNYSGG
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Attributs du produit
- This is a synthetic peptide designed for use in combination with anti-MGMT Antibody(ARP42038_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Indications d'application
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
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Stock
- -20 °C
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Stockage commentaire
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- MGMT (O6-Methylguanine-DNA-Methyltransferase (MGMT))
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Sujet
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MGMT is involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA.MGMT repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
Alias Symbols: -
Protein Interaction Partner: CREBBP,CSNK2A1,EP300,PRKACA,PRKCA,UBA1,HIST4H4,ACTB,ANP32E,ANXA1,ANXA2,CCNB1,CDK1,CDK10,CDK12,CDK2,CDKL5,CDKN1A,CREBBP,CSNK2A1,CSNK2A2,DDX24,DDX5,EEF1A1,EEF1A2,EEF1B2,EIF3H,EP300,ESR1,FBL,FBXO2,FBXO27,H2BFM,HIST1H2AM,HIST1H4A,HIST3H3,HNRNPA2B1,HNRNPC,HSP9
Protein Size: 207 -
Poids moléculaire
- 22 kDa
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ID gène
- 4255
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NCBI Accession
- NM_002412, NP_002403
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UniProt
- P16455
Antigène
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